Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Acute kidney injury
ADR ID BADD_A06560
ADR Hierarchy
20      Renal and urinary disorders
20.01      Renal disorders (excl nephropathies)
20.01.03      Renal failure and impairment
20.01.03.016      Acute kidney injury
Description A disorder characterized by the acute loss of renal function (within 2 weeks) and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction). [CTCAE] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions. | Conditions in which the function of KIDNEYS deteriorates suddenly in a matter of days or even hours. It is characterized by the sudden drop in GLOMERULAR FILTRATION RATE. [MeSH]
MedDRA Code 10069339
MeSH ID D058186; D058186; D058186
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acute kidney failure | Acute on chronic renal failure | Acute renal failure | Acute renal failure following labor and delivery | Acute renal failure following labor and delivery, postpartum condition or complication | Acute renal failure following labor and delivery, unspecified as to episode of care | Acute renal failure following labour and delivery | Acute renal failure with delivery, with mention of postpartum complication | Acute renal failure with lesion of renal cortical necrosis | Acute renal failure with lesion of renal medullary (papillary) necrosis | Acute renal failure with lesion of tubular necrosis | Acute renal failure with other specified pathological lesion in kidney | Acute renal failure, unspecified | ARF | Failure kidney acute | Kidney failure acute | Renal failure acute | Renal failure acute hypotensive | Renal failure acute ischaemic | Renal failure acute ischemic | Renal failure acute on chronic | Renal failure acute uratic | Renal shutdown acute | Shutdown renal | Acute renal insufficiency | Rhabdomyolysis-induced renal failure | Acute oliguric renal failure | Acute kidney injury | Acute Kidney Injury | Acute Kidney Injuries | Kidney Injuries, Acute | Kidney Injury, Acute | Acute Renal Injury | Acute Renal Injuries | Renal Injuries, Acute | Renal Injury, Acute | Renal Insufficiency, Acute | Acute Renal Insufficiencies | Renal Insufficiencies, Acute | Acute Renal Insufficiency | Kidney Insufficiency, Acute | Acute Kidney Insufficiencies | Kidney Insufficiencies, Acute | Acute Kidney Insufficiency | Kidney Failure, Acute | Acute Kidney Failures | Kidney Failures, Acute | Acute Renal Failure | Acute Renal Failures | Renal Failures, Acute | Renal Failure, Acute | Acute Kidney Failure
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Nuclear receptor coactivator 1Q15788Not Available
Peroxisomal acyl-coenzyme A oxidase 1Q15067Not Available
Retinoic acid receptor RXR-alphaP19793T13726
UromodulinP07911Not Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00800Erlotinib--
BADD_D00802Ertapenem0.000639%
BADD_D00809Escitalopram--
BADD_D00810Escitalopram oxalate--
BADD_D00815Esomeprazole0.000474%
BADD_D00821Estradiol--
BADD_D00843Ethanolamine oleate--
BADD_D00850Etodolac0.001978%
BADD_D00854Etoposide0.008259%
BADD_D00857Etravirine--
BADD_D00858Everolimus--
BADD_D00862Exenatide--
BADD_D00863Extendin-4--
BADD_D00868Famciclovir--
BADD_D00869Famotidine0.000656%
BADD_D00870Febuxostat0.012908%
BADD_D00871Felbamate--
BADD_D00873Fenofibrate0.001122%
BADD_D00874Fenofibric acid--
BADD_D00879Fentanyl--
BADD_D00891Fesoterodine--
BADD_D00898Finasteride--
BADD_D00902Flecainide0.003296%
BADD_D00912Fluconazole--
BADD_D00914Fludarabine0.003197%
BADD_D00931Fluorouracil0.008468%
BADD_D00932Fluoxetine--
BADD_D00935Fluphenazine--
BADD_D00936Fluphenazine decanoate--
BADD_D00937Fluphenazine hydrochloride--
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